Bhargava H N, Kasabdji D
Res Commun Chem Pathol Pharmacol. 1977 Aug;17(4):735-8.
One hr after mianserine administration brain 5-HT concentration was reduced, the greatest decrease was observed with 2.5 mg/kg dose. This reduction lasted for 1 hr. Brain 5-HT turnover was increased by all doses of mianserine used. The increase in brain 5-HT turnover after a single injection lasted for 8 hr. This increase may be related to inhibition of central 5-HT receptors.
给予米安色林1小时后，脑内5-羟色胺（5-HT）浓度降低，2.5mg/kg剂量时降低最为明显。这种降低持续1小时。所用各剂量的米安色林均可使脑内5-HT周转率增加。单次注射后，脑内5-HT周转率的增加持续8小时。这种增加可能与中枢5-HT受体的抑制有关。
