Effect of mianserine on brain serotonin turnover in mice.

One hr after mianserine administration brain 5-HT concentration was reduced, the greatest decrease was observed with 2.5 mg/kg dose. This reduction lasted for 1 hr. Brain 5-HT turnover was increased by all doses of mianserine used. The increase in brain 5-HT turnover after a single injection lasted for 8 hr. This increase may be related to inhibition of central 5-HT receptors.