同基因仓鼠的支气管致癌作用

Bronchial carcinogenesis in syngeneic hamsters.

作者信息

Fernando H C, Hammond W G, Johnson J J, Benfield J R

机构信息

Division of Cardiothoracic Surgery, University of California, Davis, School of Medicine, Sacramento 95817-2214, USA.

出版信息

Cancer Lett. 1996 Nov 29;108(2):201-4. doi: 10.1016/s0304-3835(96)04411-4.

DOI:10.1016/s0304-3835(96)04411-4

PMID:8973595

Abstract

Endobronchial sustained release implants of carcinogen were placed in males (m) and females (f) of four varieties of syngeneic hamsters: BIOF1D; BIO87.20; BIO1.5; BIO15.16. The sequential progression of carcinogenesis that occurred was faster for 1.5m than for 1.5f (P = 0.01) and less rapid for 15.16m than for 87.20m and F1Dm (P < 0.05). Fewer invasive cancers occurred in 15.16m than in the other male varieties (P < 0.01), in 1.5m than in 87.20m (P < 0.05), and in 87.20f than in 87.20m (P < 0.05). Adenocarcinoma occurred with greater frequency in the 1.5 variety than in the F1D variety (P < 0.05). Significant variability in susceptibility, incidence, and types of invasive cancers formed exists, providing new opportunities for further study of bronchial carcinogenesis.

摘要

将致癌物质的支气管内缓释植入物置于四种同基因仓鼠的雄性（m）和雌性（f）体内：BIOF1D；BIO87.20；BIO1.5；BIO15.16。发生的致癌作用的连续进展在1.5m中比在1.5f中更快（P = 0.01），在15.16m中比在87.20m和F1Dm中更慢（P < 0.05）。15.16m中发生的浸润性癌比其他雄性品种少（P < 0.01），在1.5m中比在87.20m中少（P < 0.05），在87.20f中比在87.20m中少（P < 0.05）。腺癌在1.5品种中的发生频率高于F1D品种（P < 0.05）。在形成浸润性癌的易感性、发生率和类型方面存在显著差异，为进一步研究支气管致癌作用提供了新的机会。