盘尾丝虫病中的调节活化正常T细胞表达和分泌的趋化因子：伊维菌素治疗后的变化
RANTES in onchocerciasis: changes with ivermectin treatment.
作者信息
Cooper P J, Guderian R H, Prakash D, Remick D G, Espinel I, Nutman T B, Taylor D W, Griffin G E
机构信息
Division of Infectious Diseases, St George's Hospital Medical School, London, UK.
出版信息
Clin Exp Immunol. 1996 Dec;106(3):462-7. doi: 10.1046/j.1365-2249.1996.d01-868.x.
Adverse reactions are seen relatively frequently after treatment of onchocerciasis patients with ivermectin. The chemokines RANTES and IL-8, which have both chemotactic and activation properties for eosinophils and neutrophils, respectively, may have a role in the pathogenesis of post-treatment reactions. Circulating levels of the chemokines and the cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-6 were measured in the plasma of 22 Onchocerca volvulus-infected subjects. Peaks of mean circulating levels of RANTES and TNF-alpha were seen at 6 h after ivermectin administration. Peripheral eosinophil counts declined at 36 h post-treatment and an early peak in RANTES levels was associated with a delay in peripheral eosinopenia. RANTES levels were negatively correlated with severity of rash (P < 0.001) and lymphoedema (P < 0.05), suggesting that high circulating levels of RANTES may inhibit eosinophil sequestration. No changes in circulating levels of IL-8 were seen. These findings suggest a possible role of circulating RANTES in modulating eosinophil sequestration in vivo.
用伊维菌素治疗盘尾丝虫病患者后，不良反应相对常见。趋化因子RANTES和IL-8分别对嗜酸性粒细胞和中性粒细胞具有趋化和激活特性，它们可能在治疗后反应的发病机制中起作用。在22名感染旋盘尾丝虫的受试者血浆中检测了趋化因子以及细胞因子肿瘤坏死因子-α（TNF-α）和IL-6的循环水平。在给予伊维菌素后6小时，观察到RANTES和TNF-α的平均循环水平峰值。治疗后36小时外周嗜酸性粒细胞计数下降，RANTES水平的早期峰值与外周嗜酸性粒细胞减少延迟相关。RANTES水平与皮疹严重程度（P<0.001）和淋巴水肿（P<0.05）呈负相关，提示RANTES的高循环水平可能抑制嗜酸性粒细胞隔离。未观察到IL-8循环水平的变化。这些发现提示循环RANTES在体内调节嗜酸性粒细胞隔离方面可能发挥作用。
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