在由纳氏蚋传播的盘尾丝虫病中，伊维菌素治疗的不良反应。
Adverse reactions to ivermectin treatment in Simulium neavei-transmitted onchocerciasis.
作者信息
Kipp Walter, Bamhuhiiga Jotham, Rubaale Tom, Büttner Dietrich W
机构信息
Department of Public Health Sciences, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
出版信息
Am J Trop Med Hyg. 2003 Dec;69(6):621-3.
To assess adverse effects of ivermectin treatment in a Simulium neavei-transmitted focus of onchocerciasis, a study was conducted with 1,246 patients infected with Onchocerca volvulus in eight villages in western Uganda. Study participants were treated the first time with a single dose of 150 microg/kg of ivermectin. Adverse reactions to ivermectin were determined through questioning and clinical examination during house-to-house visits to the participants within 48 hours after ivermectin treatment. Overall adverse reactions were observed in 737 (59.1%) patients. Severe reactions were rare (10 patients, 1.4%). Our data show that adverse reactions to ivermectin in an S. neavei-transmitted onchocerciasis focus in western Uganda occur frequently. In spite of the fact that many patients showed adverse reactions to ivermectin, the drug was well accepted and appreciated by the population.
为评估伊维菌素治疗在由纳氏蚋传播的盘尾丝虫病疫源地的不良反应，在乌干达西部八个村庄对1246名感染盘尾丝虫的患者进行了一项研究。研究参与者首次接受了150微克/千克单剂量伊维菌素治疗。在伊维菌素治疗后48小时内逐户走访参与者时，通过询问和临床检查确定对伊维菌素的不良反应。737名（59.1%）患者观察到总体不良反应。严重反应很少见（10名患者，1.4%）。我们的数据表明，在乌干达西部由纳氏蚋传播的盘尾丝虫病疫源地，对伊维菌素的不良反应频繁发生。尽管许多患者对伊维菌素有不良反应，但该药物仍被民众广泛接受和认可。
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