Pavlović-Kentera V, Bogdanović M, Miladinović D, Slavković V
Respiration. 1977;34(4):213-9. doi: 10.1159/000193828.
In 30 patients with respiratory insufficiency due to chronic obstructive pulmonary disease and with normal red blood cell counts, the effect of hypoxia on erythropoiesis was studied. Pronounced hypoxaemia was ascertained in all the patients by measuring PaO2. The calculated HbO2 saturation was less than 85% in group I and greater than 85% in group II, each consisting of 15 patients. Although the RBC counts and Hb concentration were within the limits of normal values, the packed RBC volume was higher than 45% in all the patients tested. The calculated MCV was increased and the erythropoietin level in plasma, indirectly measured in polycythaemic mouse bioassay, was higher than normal. Macrocytosis was shown to be PaO2-dependent and should be, according to Stohlman's data, the result of erythropoietin excess and the subsequent cessation of nucleic acid synthesis with skipped terminal division of erythroblasts in the bone marrow. The absence of erythrocytosis in these patients could be explained by a shortened survival time of macrocytes and/or other causes.
对30例慢性阻塞性肺疾病所致呼吸功能不全且红细胞计数正常的患者，研究了缺氧对红细胞生成的影响。通过测量动脉血氧分压（PaO2）确定所有患者均存在明显低氧血症。将患者分为两组，每组15例，I组计算的血红蛋白氧饱和度（HbO2）低于85%，II组高于85%。尽管红细胞计数（RBC）和血红蛋白（Hb）浓度在正常范围内，但所有受试患者的红细胞压积均高于45%。计算得出的平均红细胞体积（MCV）增加，通过多血症小鼠生物测定法间接测定的血浆促红细胞生成素水平高于正常。巨细胞增多症显示与PaO2有关，根据斯托尔曼的数据，这应该是促红细胞生成素过量以及随后骨髓中红细胞前体细胞核酸合成停止和终末分裂跳过的结果。这些患者无红细胞增多症可由大红细胞存活时间缩短和/或其他原因解释。
