Kakoi H, Anniko M
Department of Otorhinolaryngology and Head & Neck Surgery, University Hospital (Akademiska sjukhuset), Uppsala, Sweden.
Acta Otolaryngol. 1996 Nov;116(6):850-3. doi: 10.3109/00016489609137939.
Morphology of the tympanic membrane (TM) and external auditory canal (EAC) was studied in healthy, intact rat ears. TM-perforated ears (3 days after making the perforation) and TM-perforation-healed ears (14, 28 and 42 days after making the perforation). In intact ears, the epidermis in the annular region of the EAC displayed a characteristic appearance with cytoplasmic protrusions. We termed these protrusions as "finger-like projections". In contrast to the rat, the annular region of the EAC in the guinea-pig did not show "finger-like projections". Following a perforation in the centre of the anterior or the posterior quadrant of the pars tensa in rats the "finger-like projections" disappeared from the annular region on the perforated side of the EAC, while the projections remained on the malleus side of the perforation edge. In perforation-healed ears analysed 42 days after the perforation, the "finger-like projections" had recurred in the annular region on the perforated side of the EAC. The "finger-like projections" are likely to express maturation (keratinization) and desquamation of epidermal cells in the pars tensa and also could constitute morphological evidence of their migration on the TM.
在健康、完整的大鼠耳部研究了鼓膜（TM）和外耳道（EAC）的形态。对鼓膜穿孔的耳部（穿孔后3天）以及鼓膜穿孔愈合的耳部（穿孔后14、28和42天）进行了研究。在完整的耳部中，外耳道环形区域的表皮呈现出具有细胞质突起的特征性外观。我们将这些突起称为“指状突起”。与大鼠不同，豚鼠外耳道的环形区域未显示出“指状突起”。在大鼠紧张部前象限或后象限中心穿孔后，外耳道穿孔侧环形区域的“指状突起”消失，而突起仍保留在穿孔边缘的锤骨侧。在穿孔后42天分析的穿孔愈合耳部中，外耳道穿孔侧环形区域再次出现了“指状突起”。“指状突起”可能表示紧张部表皮细胞的成熟（角质化）和脱屑，也可能构成其在鼓膜上迁移的形态学证据。
