Singh J, Desiraju T, Raju T R
Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Brain Res Bull. 1996;41(6):399-408. doi: 10.1016/s0361-9230(96)00217-1.
The comparison of intracranial self-stimulation (ICSS) derived across the anteroposterior axis of medial forebrain bundle (MFB) from the anterior border of lateral hypothalamus (LH) to the ventral mesencephalon including ventral tegmental area-substantia nigra (VTA-SN) in Wistar rats was assessed through stimulation parameters and behavioural response characteristics. The interpretation of response rate/charge consumption (muC/min) with respect to rectangular wave and sine wave electrical stimulation parameters suggests that the rectangular wave parameters are better in order to get the maximum responding rates. The most vigorous and robust responding was observed in the VTA or VTA-SN boundary placements, followed by placements in medial sector of LH. The acquisition of ICSS was fastest in the case of VTA-stimulation. The next site with respect to rapidity of ICSS was posterio-ventral LH. The extinction curves indicated that it is faster and exponential in case of VTA-SN, but it is slower with longer duration in case of LH-MFB. ICSS of SN were accompanied by exploratory locomotion and head bobbing. Thirty-one percent subjects with SN/VTA stimulation showed rotational behaviour. Seventy-eight percent of subjects with LH stimulations showed stimulus-bound ejaculations. Thirty-two percent of subjects with posterior LH stimulations showed biting of pedal edges. LH stimulations were accompanied by induced seizures and increased grooming in 18% and 13% of subjects, respectively. There was lateralisation of cerebral hemispheric function as right paw preference was noted in majority of rats, whether sites of stimulation were in the left or right cerebral hemisphere. The various other modes of pedal pressing operants like use of paw and mouth, alternate paw dribbling, use of head electrode assembly to manipulate the pedal were also recorded and analysed.
通过刺激参数和行为反应特征，评估了在Wistar大鼠中，从外侧下丘脑（LH）前缘到腹侧中脑（包括腹侧被盖区 - 黑质，VTA - SN）的内侧前脑束（MFB）前后轴上获得的颅内自我刺激（ICSS）。关于矩形波和正弦波电刺激参数的反应率/电荷消耗（μC/分钟）的解释表明，矩形波参数更有利于获得最大反应率。在VTA或VTA - SN边界位置观察到最强烈和稳健的反应，其次是LH内侧区域的位置。VTA刺激时ICSS的习得最快。关于ICSS快速性的下一个部位是LH后腹侧。消退曲线表明，VTA - SN的情况更快且呈指数形式，但LH - MFB的情况则较慢且持续时间更长。SN的ICSS伴有探索性运动和点头。31%接受SN/VTA刺激的受试者表现出旋转行为。78%接受LH刺激的受试者表现出刺激束缚射精。32%接受LH后刺激的受试者表现出咬踏板边缘。LH刺激分别在18%和13%的受试者中伴有诱发性癫痫和梳理行为增加。存在大脑半球功能的偏侧化，因为在大多数大鼠中都观察到右爪偏好，无论刺激部位在左脑还是右脑半球。还记录并分析了踏板按压操作的各种其他方式，如使用爪子和嘴巴、交替爪子运球、使用头部电极组件操纵踏板等。
