Shaw J E, Parker R, Hollis S, Gokal R, Boulton A J
Department of Medicine, Manchester Royal Infirmary, UK.
Diabet Med. 1996 Dec;13(12):1033-7. doi: 10.1002/(SICI)1096-9136(199612)13:12<1033::AID-DIA280>3.0.CO;2-B.
Gustatory sweating has been only rarely reported in diabetes mellitus and is thought to be due to axonal regeneration within the autonomic nervous system. We investigated the relationship of gustatory sweating to other diabetic complications. 196 patients in four groups (diabetic nephropathy, diabetic neuropathy, diabetic controls, and non-diabetic renal failure) were questioned about gustatory sweating. Somatic and autonomic neuropathy were assessed by clinical signs, vibration perception threshold, and heart rate variability. Sixty-nine percent of patients with nephropathy and 36% of those with neuropathy reported gustatory sweating, whereas less than 5% reported it in the other two groups. Five subjects reported that gustatory sweating either disappeared or significantly improved immediately after renal transplantation. Analysis of the nephropathy and neuropathy groups separately showed a strong correlation between gustatory sweating and degree of neuropathy (p < 0.01). This study shows that gustatory sweating is much more common than previously believed and demonstrates that it is often very closely linked with diabetic nephropathy.
味觉性出汗在糖尿病患者中仅有极少的报道，被认为是由于自主神经系统内的轴突再生所致。我们研究了味觉性出汗与其他糖尿病并发症之间的关系。对四组（糖尿病肾病、糖尿病神经病变、糖尿病对照组和非糖尿病肾衰竭）的196例患者询问了味觉性出汗情况。通过临床体征、振动觉阈值和心率变异性评估躯体和自主神经病变。肾病患者中有69%以及神经病变患者中有36%报告有味觉性出汗，而其他两组中报告有味觉性出汗的不到5%。5名受试者报告称，肾移植后味觉性出汗立即消失或显著改善。分别对肾病组和神经病变组进行分析显示，味觉性出汗与神经病变程度之间存在很强的相关性（p<0.01）。本研究表明，味觉性出汗比以前认为的更为常见，并证明它通常与糖尿病肾病密切相关。
