Shaw J E, Abbott C A, Tindle K, Hollis S, Boulton A J
Department of Medicine, Manchester Royal Infirmary, UK.
Diabetologia. 1997 Mar;40(3):299-301. doi: 10.1007/s001250050677.
The treatment of gustatory sweating in diabetes mellitus is usually with oral anti-cholinergic drugs, but these frequently lead to unacceptable side effects. Glycopyrrolate is an anti-muscarinic agent that can be applied topically and is efficacious in gustatory sweating occurring in other conditions. In a double-blind placebo-controlled crossover study, we assessed the value of glycopyrrolate in 13 diabetic patients with gustatory sweating. Sweating was measured by a sweat challenge, and diaries recorded by the patients throughout the 2 weeks of each treatment period. Compared to placebo, glycopyrrolate reduced the sweat response to a challenge by 82% (p < 0.01). The frequency of episodes of gustatory sweating during the treatment period was also reduced by 51% (p < 0.01), with a nearly 100% reduction in the frequency of episodes of severe sweating (p < 0.01). In conclusion, topically applied glycopyrrolate is a very effective treatment in reducing both the severity and frequency of diabetic gustatory sweating.
糖尿病味觉性出汗的治疗通常使用口服抗胆碱能药物，但这些药物常常会导致难以接受的副作用。格隆溴铵是一种抗毒蕈碱剂，可局部应用，对其他病症引起的味觉性出汗有效。在一项双盲安慰剂对照交叉研究中，我们评估了格隆溴铵对13例糖尿病味觉性出汗患者的疗效。通过出汗激发试验测量出汗情况，患者在每个治疗期的2周内记录日记。与安慰剂相比，格隆溴铵使激发试验的出汗反应降低了82%（p<0.01）。治疗期间味觉性出汗发作的频率也降低了51%（p<0.01），严重出汗发作的频率几乎降低了100%（p<0.01）。总之，局部应用格隆溴铵是减轻糖尿病味觉性出汗严重程度和发作频率的非常有效的治疗方法。
