Cordero R, Ortiz A, Hernández R, López V, Gómez M M, Mena P
Servicio de Medicina Interna, Hospital San Sebastian, Badajoz, Spain.
Rev Esp Fisiol. 1996 Sep;52(3):167-72.
Hepatic and erythrocytic glutathione peroxidase activity, together with malondialdehyde levels, were determined as indicators of peroxidation in 83 patients from whom liver biopsies had been taken for diagnostic purposes. On histological study, the patients were classified into groups as minimal changes (including normal liver), steatosis, alcoholic hepatitis, hepatic cirrhosis, light to moderately active chronic hepatitis, and severe chronic active hepatitis. The glutathione peroxidase activity in erythrocytes showed no significant changes in any liver disease group. In the hepatic study, an increased activity was observed in steatosis with respect to the minimal changes group, this increased activity induced by the toxic agent in the initial stages of the alcoholic hepatic disease declining as the hepatic damage progressed. There was a negative correlation between the levels of hepatic malondialdehyde and hepatic glutathione peroxidase in subjects with minimal changes. This suggested the existence of an oxidative equilibrium in this group. This equilibrium is broken in the liver disease groups as was manifest in a positive correlation between malondialdehyde and glutathione peroxidase activity.
测定了83例因诊断目的接受肝脏活检患者的肝脏和红细胞谷胱甘肽过氧化物酶活性以及丙二醛水平，作为过氧化的指标。经组织学研究，将患者分为微小病变（包括正常肝脏）、脂肪变性、酒精性肝炎、肝硬化、轻度至中度活动性慢性肝炎和重度慢性活动性肝炎组。红细胞中的谷胱甘肽过氧化物酶活性在任何肝病组中均无显著变化。在肝脏研究中，与微小病变组相比，脂肪变性组的活性增加，这种由酒精性肝病初始阶段的毒性物质诱导的活性增加随着肝损伤的进展而下降。微小病变患者的肝脏丙二醛水平与肝脏谷胱甘肽过氧化物酶之间存在负相关。这表明该组存在氧化平衡。这种平衡在肝病组中被打破，表现为丙二醛与谷胱甘肽过氧化物酶活性之间呈正相关。
