De Witte P, Dahchour A, Quertemont E
University of Louvain, Laboratory of Psychobiology, Louvain-la-Neuve, Belgium.
Alcohol Alcohol Suppl. 1994;2:229-33.
Intracerebral microdialysis was used to investigate release of amino acid neurotransmitters in response to acute and chronic injection of alcohol in unanaesthetised animals. Increases in taurine levels but not of glutamate or GABA were found after acute injection of alcohol. Chronic injection of alcohol, in increasing doses over six weeks, resulted in substantially greater increases in taurine levels. Basal levels of all three amino acids were increased after chronic injection of alcohol, up to a dose of 2 g/kg body weight, but not at higher doses. Higher doses may overcome the compensatory capacity which induces increases concentrations of these neuromodulators after chronic exposure to alcohol.
在未麻醉的动物中，采用脑内微透析技术研究急性和慢性注射酒精后氨基酸神经递质的释放情况。急性注射酒精后，发现牛磺酸水平升高，但谷氨酸或γ-氨基丁酸水平未升高。在六周内逐渐增加剂量进行慢性酒精注射，导致牛磺酸水平显著升高。慢性注射酒精后，直至剂量达到2 g/kg体重时，所有三种氨基酸的基础水平均升高，但更高剂量时则不然。更高剂量可能会超过慢性酒精暴露后诱导这些神经调质浓度升高的代偿能力。
