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慢性束缚应激对海马CA3区锥体神经元树突棘及赘生物的影响——一项定量研究

Effect of chronic restraint stress on dendritic spines and excrescences of hippocampal CA3 pyramidal neurons--a quantitative study.

作者信息

Rao M S, Raju T R

机构信息

Department of Neurophysiology, National Institute of Mental Health and NeuroSciences, Bangalore, India.

出版信息

Brain Res. 1995 Oct 2;694(1-2):312-7. doi: 10.1016/0006-8993(95)00822-8.

DOI:10.1016/0006-8993(95)00822-8
PMID:8974660
Abstract

Effect of chronic restraint stress on the number of dendritic spines and excrescences of hippocampal CA3 pyramidal neurons has been investigated. The results revealed a significant increase in the number of dendritic spines of apical and basal dendrites in rats subjected to restraint stress (6 h per day for 21 days). The number of excrescences were also markedly increased in stressed rats. The physiological significance and possible mechanism for increased spine density is discussed.

摘要

研究了慢性束缚应激对海马CA3锥体神经元树突棘数量和赘生物的影响。结果显示，遭受束缚应激（每天6小时，持续21天）的大鼠顶树突和基底树突的树突棘数量显著增加。应激大鼠的赘生物数量也明显增加。讨论了棘密度增加的生理意义和可能机制。

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