Lange S, Riggert J, Humpe A, Dittmann J, Simson G, Köhler M
Abteilung für Transfusionsmedizin, Universitätsklinik Göttingen, Deutschland.
Beitr Infusionsther Transfusionsmed. 1996;33:93-7.
The effects of blood transfusion and blood donation on the immune system are still unclear. In a prospective study we investigated the effect of blood and blood component donation on several immunologic parameters. Lymphocyte subsets and cytokine levels were determined in 25 repeat whole-blood donors (RD), 25 plateletpheresis donors (PD), and 20 autologous blood donors (AD). First-time donors (FTD, n = 20) served as controls. Lymphocyte subsets and cytokines were determined using standard methods. Leukocytes, T-suppressor cells and natural killer (NK) cells were decreased in RD and PD when compared to FTD. Additionally, NK cells decreased with repeat donations in AD. No significant differences of cytokines in the different groups or during repeat autologous donations were observed.
输血和献血对免疫系统的影响仍不明确。在一项前瞻性研究中，我们调查了献血和血液成分捐献对多个免疫学参数的影响。对25名重复全血捐献者（RD）、25名单采血小板捐献者（PD）和20名自体血捐献者（AD）的淋巴细胞亚群和细胞因子水平进行了测定。首次捐献者（FTD，n = 20）作为对照。采用标准方法测定淋巴细胞亚群和细胞因子。与FTD相比，RD和PD中的白细胞、T抑制细胞和自然杀伤（NK）细胞减少。此外，AD中NK细胞随重复献血而减少。在不同组或重复自体献血过程中，未观察到细胞因子有显著差异。
