[克隆在成年大鼠大脑皮层和小脑中特异性表达的基因]
[Cloning genes, specifically expressed in the cerebral cortex and cerebellum of adult rats].
作者信息
Akopian A N, Chestkov A V, Baka I D, Bukhman V L, Georgiev G P
出版信息
Genetika. 1996 Jul;32(7):879-85.
PMID:8974908
Abstract
To isolate genes differentially expressed in the rat brain cortex and cerebellum, a subtractive cDNA cloning procedure requiring only small quantities of poly(A+) RNA, followed by differential screening, was used. Two novel genes, MK and 3L7, with cortex- and cerebellum-specific expression were identified. These genes displayed different expression patterns in the brain cortex, cerebellum, and hippocampus during postnatal development.
摘要
为了分离大鼠大脑皮层和小脑中差异表达的基因，采用了一种仅需少量聚腺苷酸加尾RNA（poly(A+) RNA）的消减cDNA克隆程序，随后进行差异筛选。鉴定出了两个具有皮层和小脑特异性表达的新基因，即MK和3L7。在出生后发育过程中，这些基因在大脑皮层、小脑和海马体中表现出不同的表达模式。
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