Iannarone C, Pennacchiotti M L, Signore L, Delogu G
Istituto di Anestesia e Rianimazione, Università degli Studi di Roma La Sapienza, Roma.
Minerva Chir. 1996 Jul-Aug;51(7-8):621-3.
The authors report a case of ethanol-induced coma treated successfully with naloxone, in a subject undergoing liver metastasis alcoholization. A dose of ethanol 95 degrees (150 ml) was injected intraoperatively into the hepatic tumor with ultrasound monitoring, in a 55-year old woman which underwent mastectomy two years ago for breast cancer. At the end of operation that went on for 128 minutes, the patient maintained during surgery with standard NLA II anaesthesia did not awake. Toxicologic testing of blood showed an alcohol concentration of 1.9 g/l. Intra-venous naloxone 2 mg was given in boluses of 0.4 mg, through a time of 30 minutes. The patient became progressively responsive with complete recovery 20 minutes later. Since fentanyl doses administered during general anaesthesia were very low, the authors believe that the postoperative coma was due to ethanol overdose. They suggest naloxone as effective treatment to reverse the depressant effects of ethanol following ultrasonically guided alcohol injection therapy.
作者报告了一例在接受肝转移瘤酒精注射治疗的患者中，用纳洛酮成功治疗乙醇诱导昏迷的病例。在一名55岁女性患者中，两年前因乳腺癌接受了乳房切除术，术中在超声监测下将一剂95度乙醇（150毫升）注入肝肿瘤内。手术持续了128分钟，结束时，接受标准NLA II麻醉的患者在手术过程中未苏醒。血液毒理学检测显示酒精浓度为1.9克/升。在30分钟内，以0.4毫克的剂量静脉推注2毫克纳洛酮。患者逐渐恢复反应，20分钟后完全康复。由于全身麻醉期间使用的芬太尼剂量非常低，作者认为术后昏迷是由于乙醇过量所致。他们建议纳洛酮作为一种有效的治疗方法，以逆转超声引导下酒精注射治疗后乙醇的抑制作用。
