Koop H
II. Innere Klinik-Gastroenterologie, Klinikum Buch, Berlin.
Praxis (Bern 1994). 1996 Nov 5;85(45):1448-50.
Infection with Helicobacter pylori (H.p.) leads to mostly asymptomatic chronic gastritis. However, H.p. plays a role in peptic ulcer, giant fold gastritis (Menetrier's disease), and possibly in gastric carcinoma and low-grade MALT lymphoma. Whether functional dyspepsia also represents a Helicobacter-induced entity is questionable. H.p. should be eradicated in patients with peptic ulcer disease, Menetrier+s disease and - but in controlled studies only - in MALT lymphomas. Triple therapy with low-dose proton pump inhibitors and two antibiotics is the most favourable treatment compared to dual therapy with omeprazole and amoxicillin/clarithromycin despite the unresolved question of the development of drug resistance.
幽门螺杆菌（H.p.）感染大多会导致无症状的慢性胃炎。然而，H.p.在消化性溃疡、巨大肥厚性胃炎（梅内特里耶病）中起作用，并且可能与胃癌和低度黏膜相关淋巴组织淋巴瘤有关。功能性消化不良是否也是由幽门螺杆菌引起的病症尚存在疑问。患有消化性溃疡病、梅内特里耶病的患者以及——但仅在对照研究中——患有黏膜相关淋巴组织淋巴瘤的患者均应根除H.p.。与奥美拉唑和阿莫西林/克拉霉素的双联疗法相比，低剂量质子泵抑制剂与两种抗生素的三联疗法是最有利的治疗方法，尽管耐药性的发展问题尚未解决。
