Handke M, Geibel A, Kasper W, Olschewski M, Simon I, Konstantinides S, Just H
Universitätsklinik Freiburg Innere Medizin III--Abteilung Kardiologie und Angiologie.
Z Kardiol. 1996 Aug;85(8):561-9.
Two-dimensional and Doppler echocardiography have been widely used for noninvasive determination of valve area in patients with mitral stenosis. Recent studies have indicated that the Doppler-echocardiographic pressure half-time method (PHT) does not accurately predict mitral orifice area (MOA). Therefore, applications of the continuity equation and the Gorlin formula have been used additionally to the PHT for Doppler-echocardiographic assessment of MOA. In a prospective study of 34 patients MOA determined by two-dimensional and Doppler echocardiography was compared with MOA measured by cardiac catheterization (range 0.40 to 1.90 cm2, mean 1.08 +/- 0.37 cm2). There was a moderate correlation between two-dimensional echocardiographic and invasive measurements (r = 0.65, SEE = 0.20 cm2). MOA calculated by the PHT showed only poor correlation with cardiac catheterization (r = 0.38 SEE = 0.37 cm2). We found better correlations for the continuity equation (r = 0.73, SEE = 0.35 cm2) and Doppler-echocardiographic application of the Gorlin formula (r = 0.81, SEe = 0.27 cm2). Doppler-echocardiographic use of the Gorlin formula yielded the best prediction of the severity of mitral valve stenosis (concordance with invasive measurement in 82%).
Pressure half-time is only a poor predictor of the severity of mitral valve stenosis. More accurate results are obtained by Doppler-echocardiographic applications of the continuity equation and especially the Gorlin formula.
二维超声心动图和多普勒超声心动图已广泛用于二尖瓣狭窄患者瓣膜面积的无创测定。最近的研究表明,多普勒超声心动图压力半衰期法(PHT)不能准确预测二尖瓣口面积(MOA)。因此,连续性方程和戈林公式已被额外用于PHT,以进行多普勒超声心动图对MOA的评估。在一项对34例患者的前瞻性研究中,将二维和多普勒超声心动图测定的MOA与心导管检查测量的MOA进行比较(范围为0.40至1.90平方厘米,平均为1.08±0.37平方厘米)。二维超声心动图测量值与侵入性测量值之间存在中度相关性(r = 0.65,标准误= 0.20平方厘米)。通过PHT计算的MOA与心导管检查仅显示出较差的相关性(r = 0.38,标准误= 0.37平方厘米)。我们发现连续性方程(r = 0.73,标准误= 0.35平方厘米)和戈林公式的多普勒超声心动图应用(r = 0.81,标准误= 0.27平方厘米)具有更好的相关性。戈林公式的多普勒超声心动图应用对二尖瓣狭窄严重程度的预测最佳(与侵入性测量结果的一致性为82%)。
压力半衰期仅是二尖瓣狭窄严重程度的较差预测指标。通过连续性方程尤其是戈林公式的多普勒超声心动图应用可获得更准确的结果。