Rácz I, Marton S, Antal I, Plachy J, Csóka G
Semmelweis Orvostudományi Egyetem Gyógyszerészeti Intézet.
Acta Pharm Hung. 1996 May;66(3):105-10.
Authors call attention on the possibilities that drug release from solid preparations can be influenced by solubility and dissolution rate according to the clinical requirements regarding the duration of action. The therapeutic time interval may be modulated influencing the rate of absorption by controlling dissolution rate and changing the transport through the membranes. The results obtained from dissolution, absorption and efficacy studies of the evaluated active substances (magnesium oxide, metoprolol, nitrofurantoin) demonstrate the significance of mass transfer processes in the drug formulation.
作者提请注意，根据关于作用持续时间的临床要求，固体制剂中的药物释放可能会受到溶解度和溶解速率的影响。治疗时间间隔可以通过控制溶解速率和改变通过膜的转运来调节吸收速率。从所评估的活性物质（氧化镁、美托洛尔、呋喃妥因）的溶解、吸收和疗效研究中获得的结果证明了药物制剂中传质过程的重要性。
