Damyanov C
Centre National d'Oncologie, Secteur Urologique, Sofia (Bulgarie).
Ann Urol (Paris). 1996;30(5):244-6.
Diagnostic cystoscopy under local anaesthesia is a frequently used method in patients with transitional cell bladder tumors. In most cases, disease recurrences detected during cystoscopic examination require additional endoscopic manipulations (TURB, laser) under general anaesthesia. In 1987, Hata et al. reported successful treatment of 5 bladder tumor patients by injection under local anaesthesia--and for diagnostic purposes--of Ethanol. Based on these preliminary results we applied the method on 12 patients with superficial bladder tumors. In the course of standard cystoscopy under local anaesthesia and using a flexible needle to penetrate the bladder, Ethanol was slowly injected into the tumor base until whitening of the tumor. Treatment was successful in 10 patients (83%) with tumor size not exceeding 2 cm. Treatment was well tolerated and no serious side effects were observed. Until the second year of follow-up no recurrences were observed at the site of ethanol injection. Sclerozing therapy with Ethanol is a therapeutic alternative for small (up to 1.2 cm) superficial tumors detected during screening of bladder cancer.
局部麻醉下的诊断性膀胱镜检查是膀胱移行细胞肿瘤患者常用的方法。在大多数情况下，膀胱镜检查中发现的疾病复发需要在全身麻醉下进行额外的内镜操作（经尿道膀胱肿瘤切除术、激光治疗）。1987年，Hata等人报告了通过局部麻醉下注射乙醇成功治疗5例膀胱肿瘤患者（用于诊断目的）。基于这些初步结果，我们将该方法应用于12例浅表性膀胱肿瘤患者。在局部麻醉下进行标准膀胱镜检查过程中，使用一根柔性针穿透膀胱，将乙醇缓慢注入肿瘤基底直至肿瘤变白。10例肿瘤大小不超过2 cm的患者治疗成功（83%）。治疗耐受性良好，未观察到严重副作用。直到随访第二年，乙醇注射部位未观察到复发。乙醇硬化治疗是膀胱癌筛查中发现的小（最大1.2 cm）浅表肿瘤的一种治疗选择。
