Schmidt C, Baumeister B, Kipnowski J, Schiermeyer-Dunkhase B, Vetter H
Medical Policlinic, University of Bonn, Germany.
Hepatogastroenterology. 1996 Nov-Dec;43(12):1508-12.
Eicosanoid mediators play an important role in the pathogenesis of chronic inflammatory bowel disease.
The synthesis of prostaglandin E2 and leukotriene B4 in biopsied colonic specimens from patients with inflammatory bowel disease was compared with that from healthy controls. In contrast to surgical resection, biopsy by colonoscopy enabled patients with milder disease to be investigated.
In subjects with Crohn's disease or ulcerative colitis, the synthesis of PGE2 was significantly (p < 0.05) increased, whereas synthesis of LTB4 remained unaltered. In addition, no differences in PGE2 and LTB4 production were found in different age groups or sex.
We conclude that prostaglandin E2, compared to leukotriene B4, is the dominant eicosanoid in moderate inflammatory bowel disease.
类二十烷酸介质在慢性炎症性肠病的发病机制中起重要作用。
将炎症性肠病患者活检结肠标本中前列腺素E2和白三烯B4的合成与健康对照者的进行比较。与手术切除不同，结肠镜活检使病情较轻的患者也能接受研究。
在克罗恩病或溃疡性结肠炎患者中，前列腺素E2的合成显著增加（p < 0.05），而白三烯B4的合成未改变。此外，不同年龄组和性别在前列腺素E2和白三烯B4生成方面未发现差异。
我们得出结论，在中度炎症性肠病中，与白三烯B4相比，前列腺素E2是主要的类二十烷酸。
