Miyata K, Taniguchi H, Tsubouchi H, Daikuhara Y, Takahashi T
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Hepatogastroenterology. 1996 Nov-Dec;43(12):1594-600.
BACKGROUND/AIMS: Human hepatocyte growth factor (hHGF), now known to be identical with scatter factor and tumor cytotoxic factor, is thought to be involved in the regeneration of the liver in humans.
We measured the levels of immunoreactive hHGF levels in peritoneal fluid before and after partial hepatectomy in 37 patients, 10 with and 27 without cirrhosis. The presence of hHGF was confirmed in human peritoneal fluid with rat hepatocytes in primary culture and Western blot.
Levels of hHGF increased significantly in peritoneal fluid after surgery, with its total concentration being correlated with the weight of resected liver 168 hours postoperatively.
Findings suggest that the hHGF levels in peritoneal fluid may indicate the extent of hepatic damage following partial hepatectomy and other liver diseases.
背景/目的：人肝细胞生长因子（hHGF），现已知其与分散因子和肿瘤细胞毒素因子相同，被认为参与人类肝脏的再生。
我们测定了37例患者在部分肝切除术前和术后腹腔液中免疫反应性hHGF的水平，其中10例有肝硬化，27例无肝硬化。通过原代培养的大鼠肝细胞和蛋白质印迹法在人腹腔液中证实了hHGF的存在。
术后腹腔液中hHGF水平显著升高，其总浓度与术后168小时切除肝脏的重量相关。
研究结果表明，腹腔液中hHGF水平可能表明部分肝切除术后及其他肝脏疾病后肝损伤的程度。
