Sumi S, Wada Y
Department of Pediatrics, Nagoya City University Medical School.
Nihon Rinsho. 1996 Dec;54(12):3226-9.
Xanthine oxidase (xanthine dehydrogenase) is composed of two identical subunits of approximately 150,000 daltons. Each subunit contains four oxdation-reduction active cofactors/monomers. In vivo, the enzyme exists mostly as the dehydrogenase type (the NAD-dependent type). The cDNA has been cloned from human liver, and the amino acid sequence has been determined. As xanthine oxidase seems to produce superoxide in postischemic reperfusion, the relation between the superoxide and postischemic tissue injury has been discussed. It has also been reported that inhibition of xanthine oxidase by allopurinol may cause severe 6-mercaptopurine toxicity.
黄嘌呤氧化酶（黄嘌呤脱氢酶）由两个约150,000道尔顿的相同亚基组成。每个亚基包含四个氧化还原活性辅因子/单体。在体内，该酶主要以脱氢酶类型（NAD依赖型）存在。其cDNA已从人肝脏中克隆出来，并且氨基酸序列已被确定。由于黄嘌呤氧化酶似乎在缺血后再灌注过程中产生超氧化物，因此已经讨论了超氧化物与缺血后组织损伤之间的关系。也有报道称，别嘌呤醇对黄嘌呤氧化酶的抑制可能会导致严重的6-巯基嘌呤毒性。
