Eernisse J G, Brand A, Repelaer van Driel O J, Dirksen T
Scand J Thorac Cardiovasc Surg. 1977;11(2):105-9.
Postoperative blood losses after open-heart surgery for Tetralogy of Fallot made re-operation imperative in 15 out of 44 patients (34%, Series A). A surgical bleeding point proved to be the causative factor in only 2 cases; the others were believed to be caused by disturbances of the haemostatic mechanism, particularly by low platelet counts, apparently due to extracorporeal circulation. Administration of a platelet suspension after disconnection of the extracorporeal circuit diminished the number of bleeding complications significantly: in a series of 58 patients (Series B), 8 re-operations (14%) were necessary. In 3 of these cases, technical reasons could be found for the blood losses. Haemodilution was carried out routinely in both series. However, the diluent contained a pasteurised protein solution in Series A and fresh frozen plasma in Series B in order to minimize the deficit of coagulation factors as much as possible.
法洛四联症心脏直视手术后的术后失血使得44例患者中有15例（34%，A组）必须再次手术。仅2例患者的手术出血点被证明是致病因素；其他患者被认为是止血机制紊乱所致，尤其是血小板计数低，显然是由于体外循环引起的。体外循环断开后给予血小板悬液显著减少了出血并发症的数量：在一组58例患者（B组）中，有8例（14%）需要再次手术。在其中3例病例中，可以找到失血的技术原因。两组均常规进行血液稀释。然而，A组的稀释剂含有经巴氏消毒的蛋白质溶液，B组含有新鲜冰冻血浆，以便尽可能减少凝血因子的缺乏。
