Lilleaasen P
Scand J Thorac Cardiovasc Surg. 1977;11(2):97-103.
Requirements of donor blood, bleeding and platelet counts were investigated during moderate and extreme haemodilution in patients undergoing aortic valve replecement. A preliminary study of 60 patients, divided in two groups of 30 patients each, was first made. A moderate haemodilution was used in one group and an extreme haemodilution with the aid of autologous transfusion was utilized in the other. As the results were interesting and encouraging, a randomized study was performed. Thirty patients, divided in two groups of 15 patients each, were investigated. The degree of dilution was essentially similar to that of the corresponding moderate and extreme haemodilution groups in the preliminary study. An average reduction of 71% in the requirement of donor blood and of 47% in postoperative chest tube drainage was found in the patients in the extreme dilution group. The circulating platelet counts fell less during and after the operation in this group than in the moderately diluted patients. After adjustment for the dilution, the platelet counts fell to about 60% in the moderate dilution group during the perfusion, but rose to about 130% in the extremely diluted patients. These findings are discussed.
对接受主动脉瓣置换术的患者在中度和极度血液稀释期间的供血需求、出血量和血小板计数进行了研究。首先对60例患者进行了初步研究，将其分为两组，每组30例。一组采用中度血液稀释，另一组借助自体输血进行极度血液稀释。由于结果有趣且令人鼓舞，遂进行了一项随机研究。对30例患者进行了调查，将其分为两组，每组15例。稀释程度与初步研究中相应的中度和极度血液稀释组基本相似。在极度稀释组患者中，供血需求平均减少了71%，术后胸管引流量平均减少了47%。该组患者术中及术后循环血小板计数的下降幅度低于中度稀释患者。调整稀释因素后，中度稀释组患者在灌注期间血小板计数降至约60%，而极度稀释患者的血小板计数则升至约130%。对这些发现进行了讨论。
