Diegelmann R F
Wound Healing Center, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
J Urol. 1997 Jan;157(1):298-302.
We can look at tissue injury as if a picket fence were damaged by the process of trauma. A fetus has the capability to repair the fence so that it is almost identical to what it was before the injury. In contrast, in adults the wound healing response can normally put the fence back together so that it is still functional, although its appearance may not be optimal. In the case of a hypertrophic scar too many pickets have been replaced in the fence, and neither the function nor the appearance is optimal. Perhaps when we understand the process by which the fetus heals and hypertrophic scars over heal, we can apply this information to some of the complex problems seen in such conditions as Peyronie's disease and Dupuytren's contracture.
我们可以将组织损伤看作是一排尖桩篱栅在创伤过程中遭到破坏。胎儿有能力修复这排篱栅，使其几乎与损伤前一模一样。相比之下，成年人的伤口愈合反应通常能将篱栅重新拼合起来，使其仍具功能，尽管外观可能并非最佳。在增生性瘢痕的情况下，篱栅中更换了过多的尖桩，功能和外观都不理想。也许当我们了解胎儿愈合以及增生性瘢痕过度愈合的过程时，就能将这些信息应用于佩罗尼氏病和掌腱膜挛缩症等病症中出现的一些复杂问题。
