Boudousquie A C, Lawce H J, Sherman R, Olson S, Magenis R E, Corless C L
Department of Pathology, University Hospital, Oregon Health Sciences University, Portland 97201, USA.
Cancer Genet Cytogenet. 1996 Dec;92(2):116-21. doi: 10.1016/s0165-4608(96)00175-6.
We describe a malignant epithelioid hemangioendothelioma arising in the back of a 45-year-old man with pulmonary and bone marrow metastases. Light microscopic and immunohistochemical features of this tumor are presented. Karyotyping revealed several clonal abnormalities: a complex unbalanced translocation [7;22] involving multiple breakpoints (confirmed by fluorescence in situ hybridization), a Robertsonian t(14;14), and loss of the Y chromosome. Monosomy for chromosome 11 was noted in a subset of the tumor cells. To our knowledge a karyotype has not been previously reported for this unusual vascular tumor.
