Lee H H, Farber J M
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda MD 20892, USA.
Cytogenet Cell Genet. 1996;74(4):255-8. doi: 10.1159/000134428.
MIG is a gamma interferon-inducible T cell chemoattractant that is a member of the chemokine family of cytokines. P1 clones containing the MIG gene were found also to contain the gene of a related chemokine, INP10. We localized MIG and INP10 to 4q21 by FISH, demonstrated by pulsed field gel electrophoresis that MIG and INP10 are distant from the tight cluster of other CXC chemokine genes at 4q12-->q13, and determined that MIG and INP10 are oriented head to tail with their start codons separated by less than 16 kb.
MIG是一种γ干扰素诱导的T细胞趋化因子，属于细胞因子趋化因子家族成员。发现含有MIG基因的P1克隆也含有相关趋化因子INP10的基因。我们通过荧光原位杂交（FISH）将MIG和INP10定位到4q21，脉冲场凝胶电泳表明MIG和INP10与4q12→q13处其他CXC趋化因子基因的紧密簇距离较远，并确定MIG和INP10头对头排列，其起始密码子间隔小于16kb。
