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Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids.

作者信息

Modi W S, Chen Z Q

机构信息

Intramural Research Support Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Maryland 21702-1201, USA.

出版信息

Genomics. 1998 Jan 1;47(1):136-9. doi: 10.1006/geno.1997.5100.

DOI:10.1006/geno.1997.5100
PMID:9465307
Abstract

All 12 of the human CXC chemokine genes were physically mapped using gene-specific PCR primers and the GenBridge 4 radiation hybrid panel. Nine genes, PF4, PF4V1, GRO1, GCP2, PPBP, IL8, GRO2, GRO3, and SCYB5, were assigned within a 1.8-cR interval of one another on 4q. Two additional genes, MIG and INP10, map within 0.5 cR of each another and 6 cR distal to the above-mentioned group. The final gene, SDF1, is localized on 10q. Phylogenetic analyses of amino acid sequences revealed that SDF1 is the most divergent member and that the physically separated MIG-INP10 pair constitutes a distinct evolutionary lineage.

摘要

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