Zürcher H U, Meier H R, Huber M, Lämmli J, Wick A, Binswanger U
Schweiz Med Wochenschr. 1977 Jul 23;107(29):1025-8.
Acute urate nephropathy during starvation for weight reduction has been observed in 2 patients. Under these conditions ketoacidosis causes impaired renal uric acid excretion and hyperuricemia. Uricosuric agents or sudden intake of normal calorie diet induces massive uricosuria and kidney damage. Uricosuric agents should be avoided and steps taken to promote abundant diuresis, while allopurinol should be prescribed.
在2例为减轻体重而节食的患者中观察到急性尿酸盐肾病。在这些情况下，酮症酸中毒会导致肾脏尿酸排泄受损和高尿酸血症。促尿酸排泄药或突然摄入正常热量饮食会引发大量尿酸尿和肾损伤。应避免使用促尿酸排泄药，并采取措施促进大量利尿，同时应开具别嘌醇。
