一种检测晶状体中8-甲氧基补骨脂素的方法。
A method for detecting 8-methoxypsoralen in the ocular lens.
作者信息
Lerman S, Borkman R F
出版信息
Science. 1977 Sep 23;197(4310):1287-88. doi: 10.1126/science.897669.
PMID:897669
Abstract
The use of 8-methoxypsoralen for treating psoriasis could prove hazardous if this photosensitizing agent enters the ocular lens. Phosphorescence spectra of intact rat lenses reveal concentrations of 8-methoxypsoralen on the order 10(-5)M after intraperitoneal injection of 8-methoxypsoralen. There is evidence that this drug can function as a photosensitizing agent, enhancing ultraviolet-induced changes within the lens.
摘要
如果这种光敏剂进入眼晶状体，使用8-甲氧基补骨脂素治疗牛皮癣可能会有危险。完整大鼠晶状体的磷光光谱显示，腹腔注射8-甲氧基补骨脂素后，其浓度约为10^(-5)M。有证据表明，这种药物可作为一种光敏剂，增强紫外线引起的晶状体变化。
Zotero 插件