Rai V, Hopkisson J, Kennedy S, Bergqvist A, Barlow D H, Mardon H J
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford OX39DC, U.K.
J Pathol. 1996 Oct;180(2):181-7. doi: 10.1002/(SICI)1096-9896(199610)180:2<181::AID-PATH620>3.0.CO;2-I.
The expression of integrin subunits has been investigated in the stroma and epithelium of eutopic and ectopic endometrial tissues, using immunohistochemistry and fluorescently activated cell-sorting techniques. Integrin subunits exhibited tissue-specific expression in both eutopic and ectopic endometrium. Integrin alpha 3 subunit was up-regulated in ectopic endometrium compared with the eutopic counterpart, whereas alpha 6 integrin subunit was down-regulated in the ectopic tissues. Cycle stage-dependent expression of alpha v and beta 3, observed in eutopic endometrium, was absent in the ectopic counterpart. It is concluded that the development and regeneration of the endometrium involve complex integrin-ligand interactions and that regulation of specific adhesive events is lost in endometriosis.
运用免疫组织化学和荧光激活细胞分选技术，对在位和异位子宫内膜组织的基质及上皮中整合素亚基的表达情况进行了研究。整合素亚基在位和异位子宫内膜中均呈现出组织特异性表达。与在位子宫内膜相比，整合素α3亚基在异位子宫内膜中表达上调，而α6整合素亚基在异位组织中表达下调。在位子宫内膜中观察到的αv和β3的周期阶段依赖性表达，在异位子宫内膜中未出现。得出的结论是，子宫内膜的发育和再生涉及复杂的整合素-配体相互作用，且在子宫内膜异位症中特定黏附事件的调控丧失。
