盐酸林西多明在猴子体内的海绵体内注射：长期使用无毒性作用。
Intracavernous injection of linsidomine chlorhydrate in monkeys: lack of toxic effect with long-term use.
作者信息
von Heyden B, Brock G B, Martinez-Piñeiro L, Lue T F
机构信息
Department of Urology, University of California, School of Medicine, San Francisco, USA.
出版信息
Eur Urol. 1996;30(4):502-5. doi: 10.1159/000474224.
OBJECTIVE
We sought to investigate whether linsidomine chlorhydrate (SIN1, the active metabolite of molsidomine and a nitric oxide donor) has a toxic effect when used chronically for the treatment of impotence.
METHODS
We gave 50 intracavernous injection of 1.5 mg SIN1 over 25 weeks to each of 5 monkeys.
RESULTS
Four monkeys consistently responded with erections of sufficient rigidity and duration (mean 47.5 +/- 3.3 min), and none of the five evidenced histopathologic changes of the cavernous tissue.
CONCLUSION
SIN1 appears to be a safe option for the pharmacotherapy of erectile dysfunction.
目的
我们试图研究盐酸林西多明（SIN1，吗多明的活性代谢产物且为一氧化氮供体）长期用于治疗阳痿时是否具有毒性作用。
方法
我们对5只猴子中的每只在25周内每周进行1.5毫克SIN1的海绵体内注射。
结果
4只猴子持续出现硬度和持续时间足够的勃起（平均47.5 +/- 3.3分钟），并且5只猴子均未出现海绵体组织的组织病理学变化。
结论
SIN1似乎是勃起功能障碍药物治疗的安全选择。
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