Ikeda M, Hiroshige K, Abiko Y, Onoda K
Department of Otolaryngology, Nihon University School of Medicine, Tokyo, Japan.
J Laryngol Otol. 1996 Oct;110(10):918-21. doi: 10.1017/s0022215100135352.
The possible involvement of depression on cellular immunity in reactivation of varicella-zoster virus (VZV) in herpes zoster oticus was investigated. The subjects comprised 59 cases of herpes zoster oticus, 33 cases of herpes zoster sine herpete (ZSH) with facial paralysis, and 205 cases of Bell's palsy. The transformation rate of lymphocytes to phytohaemagglutinin in herpes zoster oticus tended to be lower than that in Bell's palsy. In skin tests with purified protein derivatives of tuberculin, the positivity rate in herpes zoster oticus was significantly lower than that in Bell's palsy (p < 0.015). In skin tests using VZV antigen the positivity rate in herpes zoster oticus and ZSH were significantly lower than that of Bell's palsy (p < 0.001 and p < 0.015, respectively). Thus, it was noted that cellular immunity, especially specific cellular immunity against VZV, was significantly depressed in herpes zoster oticus and ZSH. We consider that depression of specific cellular immunity plays an important role in triggering reactivation of VZV and onset of these diseases.
研究了抑郁症在耳带状疱疹中水痘 - 带状疱疹病毒（VZV）再激活过程中对细胞免疫的可能影响。研究对象包括59例耳带状疱疹患者、33例伴有面瘫的无疱疹性带状疱疹（ZSH）患者以及205例贝尔麻痹患者。耳带状疱疹患者淋巴细胞对植物血凝素的转化率往往低于贝尔麻痹患者。在结核菌素纯蛋白衍生物皮肤试验中，耳带状疱疹患者的阳性率显著低于贝尔麻痹患者（p < 0.015）。在使用VZV抗原的皮肤试验中，耳带状疱疹患者和ZSH患者的阳性率显著低于贝尔麻痹患者（分别为p < 0.001和p < 0.015）。因此，注意到在耳带状疱疹和ZSH中细胞免疫，尤其是针对VZV的特异性细胞免疫显著降低。我们认为特异性细胞免疫的降低在触发VZV再激活和这些疾病的发病中起重要作用。
