Terada K, Niizuma T, Kawano S, Kataoka N, Akisada T, Orita Y
Department of Pediatrics, Kawasaki Medical School, Kurashiki, Okayama, Japan.
J Med Virol. 1998 Dec;56(4):359-63.
On the basis of alterations in varicella-zoster virus (VZV) antibody titers, it appears that Bell's palsy in some patients could be associated with VZV reactivation, that is, zoster sine herpete. To obtain stronger evidence of this association, polymerase chain reaction (PCR) was used to detect VZV DNA in auricular lesions or peripheral blood mononuclear cells (PBMCs) from Bell's palsy or Ramsay Hunt syndrome patients. VZV DNA was detected in the auricular lesions of Ramsay Hunt syndrome, in PBMCs from 2 Ramsay Hunt syndrome patients, and in 4 of 17 samples from 16 Bell's palsy patients. Three of these four positive patients were thought to have zoster sine herpete because of hearing difficulty, vertigo, and pain. VZV IgM antibodies were positive in 1 of the 2 patients with Ramsay Hunt syndrome, and in 2 of the 17 samples from the Bell's palsy patients. VZV IgG antibody titers during the acute phase were significantly higher in the patients positive for the PCR or VZV IgM antibody than in those negative for them. These findings provide evidence that Bell's palsy in some patients could be associated with VZV reactivation.
基于水痘-带状疱疹病毒（VZV）抗体滴度的变化，似乎某些患者的贝尔麻痹可能与VZV再激活有关，即无疱疹性带状疱疹。为了获得这种关联的更有力证据，采用聚合酶链反应（PCR）检测贝尔麻痹或拉姆齐·亨特综合征患者耳部病变或外周血单个核细胞（PBMC）中的VZV DNA。在拉姆齐·亨特综合征的耳部病变中、2例拉姆齐·亨特综合征患者的PBMC中以及16例贝尔麻痹患者的17份样本中的4份中检测到了VZV DNA。这4例阳性患者中有3例因听力困难、眩晕和疼痛被认为患有无疱疹性带状疱疹。2例拉姆齐·亨特综合征患者中有1例VZV IgM抗体呈阳性，贝尔麻痹患者的17份样本中有2份呈阳性。PCR或VZV IgM抗体阳性患者急性期的VZV IgG抗体滴度显著高于阴性患者。这些发现提供了证据，表明某些患者的贝尔麻痹可能与VZV再激活有关。
