酯酶-P是由黑腹果蝇中的一个隐蔽假基因编码的吗？
Is esterase-P encoded by a cryptic pseudogene in Drosophila melanogaster?
作者信息
Balakirev E S, Ayala F J
机构信息
Department of Ecology and Evolutionary Biology, University of California, Irvine 92697-2525, USA.
出版信息
Genetics. 1996 Dec;144(4):1511-8. doi: 10.1093/genetics/144.4.1511.
Abstract
We have amplified and sequenced the gene encoding Esterase-P (Est-P) in 10 strains of Drosophila melanogaster. Three premature termination codons occur in the coding region of the gene in two strains. This observation, together with other indirect evidence, leads us to propose that Est-P may be a pseudogene in D. melanogaster. Est-P would be a "cryptic" pseudogene, in the sense that it retains intact the coding sequence (without stop codons and other alterations usually observed in pseudogenes) in most D. melanogaster strains. We conjecture that the beta-esterase cluster may consist in other Drosophila species of functional and nonfunctional genes. We also conjecture that the rarity of detected pseudogenes in Drosophila may be due to the difficulty of discovering them, because most of them are cryptic.
摘要
我们对10株黑腹果蝇中编码酯酶-P（Est-P）的基因进行了扩增和测序。在两个菌株的该基因编码区出现了三个提前终止密码子。这一观察结果，连同其他间接证据，使我们提出Est-P在黑腹果蝇中可能是一个假基因。从某种意义上说，Est-P将是一个“隐性”假基因，因为在大多数黑腹果蝇菌株中它保留了完整的编码序列（没有终止密码子和通常在假基因中观察到的其他改变）。我们推测，在其他果蝇物种中，β-酯酶簇可能由功能基因和非功能基因组成。我们还推测，果蝇中检测到的假基因很少，可能是由于发现它们的难度，因为它们大多是隐性的。
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