Mom1是Min/+小鼠肠道腺瘤大小和数量的半显性修饰基因。
Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice.
作者信息
Gould K A, Dietrich W F, Borenstein N, Lander E S, Dove W F
机构信息
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706, USA.
出版信息
Genetics. 1996 Dec;144(4):1769-76. doi: 10.1093/genetics/144.4.1769.
Abstract
The intestinal tumor multiplicity in mice heterozygous for ApcMin is strongly modulated by genetic background. On the sensitive C57BL/6J (B6) background, mice develop large numbers of intestinal adenomas. The AKR/J (AKR) strain carries alleles that correlate with a strong reduction in tumor multiplicity. To study the effect of one of these modifiers, Mom1, we have generated a mouse line in which the AKR allele of Mom1 is carried on the sensitive B6 genetic background. This strain was produced by using a marker-assisted selection method to eliminate unlinked AKR alleles more rapidly. The application and efficiency of this method are discussed. We used this strain to determine that Mom1 affects both tumor multiplicity and tumor size in a semi-dominant fashion.
摘要
ApcMin杂合子小鼠的肠道肿瘤多发性受到遗传背景的强烈调控。在敏感的C57BL/6J（B6）背景下，小鼠会产生大量肠道腺瘤。AKR/J（AKR）品系携带的等位基因与肿瘤多发性的显著降低相关。为了研究其中一个修饰基因Mom1的作用，我们培育了一个小鼠品系，其Mom1的AKR等位基因位于敏感的B6遗传背景上。该品系是通过使用标记辅助选择方法更快地消除不连锁的AKR等位基因而产生的。本文讨论了该方法的应用及效率。我们使用这个品系确定Mom1以半显性方式影响肿瘤多发性和肿瘤大小。
相似文献
1
Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice.Mom1是Min/+小鼠肠道腺瘤大小和数量的半显性修饰基因。
Genetics. 1996 Dec;144(4):1769-76. doi: 10.1093/genetics/144.4.1769.
2
A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice.一种导致肠道肿瘤不完全显性以及ApcMin/+小鼠杂合性缺失减少的抗性遗传背景。
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10826-31. doi: 10.1073/pnas.95.18.10826.
3
Localized gene action controlling intestinal neoplasia in mice.控制小鼠肠道肿瘤形成的局部基因作用
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5848-53. doi: 10.1073/pnas.94.11.5848.
4
Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.ApcMin/+ Mom1S小鼠腺瘤多发性变异的遗传基础。
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2868-73. doi: 10.1073/pnas.0500039102. Epub 2005 Feb 14.
5
Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to ApcMin intestinal tumorigenesis.对相互同源近交系的分析表明，C3H/HeJ基因组对ApcMin肠道肿瘤发生具有高度抗性。
Genomics. 2004 Nov;84(5):844-52. doi: 10.1016/j.ygeno.2004.07.010.
6
Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia.Min 2（Mom2）位点修饰因子的鉴定，一种影响Apc诱导的肠道肿瘤形成的新突变。
Genome Res. 2002 Jan;12(1):88-97. doi: 10.1101/gr.206002.
7
Action of Min and Mom1 on neoplasia in ectopic intestinal grafts.Min和Mom1对异位肠移植瘤形成的作用。
Cell Growth Differ. 1996 Oct;7(10):1361-8.
8
Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.小鼠肠道肿瘤形成的Mom1修饰基因的候选基因的遗传评估。
Genetics. 1996 Dec;144(4):1777-85. doi: 10.1093/genetics/144.4.1777.
9
10
The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions.肠道上皮及其肿瘤：遗传、细胞和组织间的相互作用
Philos Trans R Soc Lond B Biol Sci. 1998 Jun 29;353(1370):915-23. doi: 10.1098/rstb.1998.0256.
引用本文的文献
1
Mouse models in colon cancer, inferences, and implications.结肠癌的小鼠模型、推断及意义。
iScience. 2023 May 25;26(6):106958. doi: 10.1016/j.isci.2023.106958. eCollection 2023 Jun 16.
2
Estrogen receptor alpha promotes lupus in (NZB×NZW)F1 mice in a B cell intrinsic manner.雌激素受体α以B细胞内在方式促进（NZB×NZW）F1小鼠患狼疮。
Clin Immunol. 2017 Jan;174:41-52. doi: 10.1016/j.clim.2016.10.011. Epub 2016 Oct 29.
3
Somatic recombination in adult tissues: What is there to learn?成年组织中的体细胞重组：有什么可了解的？
Fly (Austin). 2017 Apr 3;11(2):121-128. doi: 10.1080/19336934.2016.1249073. Epub 2016 Nov 11.
4
Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer.在结直肠癌小鼠模型中对DNA修复能力的操控
Biomed Res Int. 2016;2016:1414383. doi: 10.1155/2016/1414383. Epub 2016 Jun 20.
5
Eric Lander and David Botstein on Mapping Quantitative Traits.埃里克·兰德和大卫·博特斯坦论数量性状定位
Genetics. 2016 May;203(1):1-3. doi: 10.1534/genetics.116.189803. Epub 2016 May 5.
6
The Effects of Genetic Background of Mouse Models of Cancer: Friend or Foe?癌症小鼠模型的遗传背景效应：助力还是阻力？
Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.top076273. doi: 10.1101/pdb.top076273.
7
Mouse models of intestinal cancer.肠道癌的小鼠模型。
J Pathol. 2016 Jan;238(2):141-51. doi: 10.1002/path.4645. Epub 2015 Oct 29.
8
Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice.miR-10a的缺失激活了lpo，并在雌性小鼠肠道肿瘤形成过程中与激活的Wnt信号协同作用。
PLoS Genet. 2013 Oct;9(10):e1003913. doi: 10.1371/journal.pgen.1003913. Epub 2013 Oct 24.
9
Identification of five novel modifier loci of Apc(Min) harbored in the BXH14 recombinant inbred strain.鉴定 BXH14 重组近交系中存在的五个新型 Apc(Min) 修饰基因座。
Carcinogenesis. 2012 Aug;33(8):1589-97. doi: 10.1093/carcin/bgs185. Epub 2012 May 24.
10
Clonal structure of carcinogen-induced intestinal tumors in mice.致癌剂诱导的小鼠肠道肿瘤的克隆结构。
Cancer Prev Res (Phila). 2011 Jun;4(6):916-23. doi: 10.1158/1940-6207.CAPR-11-0022.
本文引用的文献
1
Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse.Mom-1的基因鉴定，Mom-1是影响小鼠Min诱导的肠道肿瘤形成的一个主要修饰位点。
Cell. 1993 Nov 19;75(4):631-9. doi: 10.1016/0092-8674(93)90484-8.
2
The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.分泌型磷脂酶A2基因是Mom1位点的一个候选基因，Mom1位点是ApcMin诱导的肠道肿瘤形成的主要修饰因子。
Cell. 1995 Jun 16;81(6):957-66. doi: 10.1016/0092-8674(95)90015-2.
3
ApcMin: a mouse model for intestinal and mammary tumorigenesis.ApcMin：一种用于肠道和乳腺肿瘤发生的小鼠模型。
Eur J Cancer. 1995 Jul-Aug;31A(7-8):1061-4. doi: 10.1016/0959-8049(95)00181-h.
4
Suppression of intestinal neoplasia by DNA hypomethylation.DNA低甲基化对肠道肿瘤的抑制作用。
Cell. 1995 Apr 21;81(2):197-205. doi: 10.1016/0092-8674(95)90329-1.
5
DNA fingerprints applied to gene introgression in breeding programs.应用于育种计划中基因渐渗的DNA指纹图谱。
Genetics. 1990 Mar;124(3):783-9. doi: 10.1093/genetics/124.3.783.
6
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.一种导致小鼠发生多发性肠道肿瘤的显性突变。
Science. 1990 Jan 19;247(4940):322-4. doi: 10.1126/science.2296722.
7
The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.Min（多发性肠道肿瘤）突变：其对肠道上皮细胞分化的影响以及与修饰系统的相互作用。
J Cell Biol. 1992 Mar;116(6):1517-26. doi: 10.1083/jcb.116.6.1517.
8
Using markers in gene introgression breeding programs.在基因渐渗育种计划中使用标记。
Genetics. 1992 Dec;132(4):1199-210. doi: 10.1093/genetics/132.4.1199.
9
A genetic map of the mouse suitable for typing intraspecific crosses.一张适用于种内杂交分型的小鼠遗传图谱。
Genetics. 1992 Jun;131(2):423-47. doi: 10.1093/genetics/131.2.423.
Zotero 插件