Friston K J, Malizia A L, Wilson S, Cunningham V J, Jones T, Nutt D J
Wellcome Department of Cognitive Neurology, National Hospital, London, UK.
J Cereb Blood Flow Metab. 1997 Jan;17(1):80-93. doi: 10.1097/00004647-199701000-00011.
We present a simple way of assessing dynamic or time-dependent changes in displacement during single-subject radioligand positron emission tomography (PET) activation studies. The approach is designed to facilitate dynamic activation studies using selective radioligands. These studies are, in principle, capable of characterising functional neurochemistry by analogy with the study of functional neuroanatomy using rCBF activation studies. The proposed approach combines time-dependent compartmental models of tracer kinetics and the general linear model used in statistical parametric mapping. This provides for a comprehensive, voxel-based and data-led assessment of regionally specific effects. The statistical model proposed in this paper is predicated on a single-compartment model extended to allow for time-dependent changes in kinetics. We have addressed the sensitivity and specificity of the analysis, as it would be used operationally, by applying the analysis to 11C-Flumazenil dynamic displacement studies. The activation used in this demonstration study was a pharmacological (i.v. midazolam) challenge, 30 min after administration of the tracer. We were able to demonstrate, and make statistical inferences about, regional increases in k2 (or decreases in the volume of distribution) in prefrontal and other cortical areas.
我们提出了一种在单受试者放射性配体正电子发射断层扫描（PET）激活研究中评估位移动态或随时间变化的简单方法。该方法旨在促进使用选择性放射性配体的动态激活研究。原则上，这些研究能够通过与使用rCBF激活研究的功能性神经解剖学研究类比来表征功能性神经化学。所提出的方法结合了示踪剂动力学的时间依赖性隔室模型和统计参数映射中使用的一般线性模型。这提供了一种基于体素且以数据为主导的对区域特异性效应的全面评估。本文提出的统计模型基于一个单隔室模型，该模型经过扩展以允许动力学随时间变化。我们通过将该分析应用于11C-氟马西尼动态位移研究，探讨了其在实际应用中的敏感性和特异性。本示范研究中使用的激活是在注射示踪剂30分钟后进行的药理学（静脉注射咪达唑仑）激发。我们能够证明并对前额叶和其他皮质区域中k2的区域增加（或分布体积的减少）进行统计推断。
