Kuzniecky R I, Barkovich A J
UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, 35294, USA.
J Clin Neurophysiol. 1996 Nov;13(6):468-80. doi: 10.1097/00004691-199611000-00002.
This article reviews the pathogenesis and pathology of the most common focal malformations of cortical development in association with epilepsy. The classification of these disorders is reviewed in the context of new developments in the areas of diagnosis and genetics. The major pathological substrates and the possible mechanisms of these malformations are discussed. The possible mechanisms of epileptogenesis in the context of focal malformations are complex and poorly understood at present. Advances in this area promise to enhance our understanding of the basic mechanisms of epilepsy.
本文综述了与癫痫相关的最常见皮质发育局灶性畸形的发病机制和病理学。结合诊断和遗传学领域的新进展，对这些疾病的分类进行了综述。讨论了这些畸形的主要病理基础和可能机制。在局灶性畸形背景下癫痫发生的可能机制目前较为复杂且了解甚少。该领域的进展有望增进我们对癫痫基本机制的理解。
