Flint A C, Kriegstein A R
Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Curr Opin Neurol. 1997 Apr;10(2):92-7. doi: 10.1097/00019052-199704000-00004.
Neuronal migration disorders are often associated with intractable epilepsy. These cortical malformations are quite heterogeneous, suggesting that they may result from interference with a diverse set of processes during corticogenesis. Progress toward understanding the pathophysiologic basis of these disorders is coming from research into the basic mechanisms of corticogenesis, animal models of cortical malformations, and molecular genetic approaches to migration disorders.
神经元迁移障碍常与难治性癫痫相关。这些皮质畸形具有很大的异质性，这表明它们可能是由于在皮质发生过程中多种过程受到干扰所致。对这些疾病病理生理基础的理解进展来自于对皮质发生基本机制的研究、皮质畸形动物模型以及针对迁移障碍的分子遗传学方法。
