Parras Carlos, García-Alonso L A, Rodriguez I, Jiménez F
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma, Madrid, Spain.
EMBO J. 1996 Dec 2;15(23):6394-9.
Formation of neural precursors in Drosophila is determined by proneural genes. The distinctive pattern of expression of some genes of the achaete-scute complex in the embryonic neuroectoderm has prompted the speculation that they could also function in the specification of neural precursor identity in the CNS. To test this hypothesis, we have analysed the capacity of different proneural proteins to promote the development of a particular CNS precursor, the MP2 precursor. Our results indicate that: (i) all known proneural proteins are similarly able to support the formation of a neural precursor at the position of MP2; (ii) different proneural proteins promote the expression of different characteristics of MP2; and (iii) a totally normal specification of the MP2 fate can only be attained by the proneural genes achaete or scute.
果蝇中神经前体的形成由原神经基因决定。achaete - scute复合体的一些基因在胚胎神经外胚层中独特的表达模式引发了这样的推测：它们也可能在中枢神经系统神经前体身份的特化过程中发挥作用。为了验证这一假设，我们分析了不同原神经蛋白促进特定中枢神经系统前体MP2前体发育的能力。我们的结果表明：（i）所有已知的原神经蛋白都同样能够支持在MP2位置形成神经前体；（ii）不同的原神经蛋白促进MP2不同特征的表达；（iii）只有原神经基因achaete或scute才能实现MP2命运的完全正常特化。
