离散调控区域控制 D-Pax2 在外部感觉器官发育过程中的早期和晚期表达。
Discrete regulatory regions control early and late expression of D-Pax2 during external sensory organ development.
机构信息
Department of Biology, Colby College, Waterville, Maine, USA.
出版信息
Dev Dyn. 2011 Jul;240(7):1769-78. doi: 10.1002/dvdy.22672. Epub 2011 Jun 3.
Abstract
The transcription factor D-Pax2 is required for the correct differentiation of several cell types in Drosophila sensory systems. While the regulation of its expression in the developing eye has been well studied, little is known about the mechanisms by which the dynamic pattern of D-Pax2 expression in the external sensory organs is achieved. Here we demonstrate that early activation of D-Pax2 in the sensory organ lineage and its maintenance in the trichogen and thecogen cells are governed by separate enhancers. Furthermore, the initial activation is controlled in part by proneural proteins whereas the later maintenance expression is regulated by a positive feedback loop.
摘要
转录因子 D-Pax2 对于果蝇感觉系统中几种细胞类型的正确分化是必需的。虽然其在发育中的眼睛中的表达调控已经得到了很好的研究，但对于在外感器官中 D-Pax2 表达的动态模式是如何实现的机制知之甚少。在这里，我们证明了 D-Pax2 在感觉器官谱系中的早期激活及其在毛原细胞和鞘原细胞中的维持是由独立的增强子控制的。此外，初始激活部分受神经前蛋白控制，而后期维持表达则受正反馈环调控。
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