Seriolo B, Accardo S, Fasciolo D, Bertolini S, Cutolo M
Division of Rheumatology, University of Genova, Italy.
Clin Exp Rheumatol. 1996 Nov-Dec;14(6):593-9.
To investigate lipoprotein levels in rheumatoid arthritis (RA) patients with and without anticardiolipin antibody (aCL) positivity and to evaluate whether an abnormal lipid profile might be associated with an altered risk of vascular disorders.
137 female patients were evaluated for their aCL levels (isotypes IgG and IgM); concentrations of plasma lipids, lipoproteins, and apolipoproteins; and for the occurrence of thrombotic events. The patients were grouped according to their aCL positivity.
Higher rates of venous and/or arterial thrombosis were diagnosed in all the RA patients compared to the controls (p = 0.01). Lower levels of the high density lipoprotein cholesterol, apolipoprotein AI, were found in these patients (p = 0.001). Higher levels of lipoprotein (a) were observed in RA patients when compared to controls in both aCL positive and negative RA patients (P = 0.001 and p = 0.01, respectively).
The presence of aCL and an altered lipid profile may represent an important risk factor for thrombotic events in patients affected by RA.
研究有无抗心磷脂抗体（aCL）阳性的类风湿关节炎（RA）患者的脂蛋白水平，并评估异常血脂谱是否可能与血管疾病风险改变相关。
对137名女性患者进行了aCL水平（IgG和IgM亚型）、血浆脂质、脂蛋白和载脂蛋白浓度以及血栓形成事件的评估。患者根据aCL阳性情况分组。
与对照组相比，所有RA患者中静脉和/或动脉血栓形成的诊断率更高（p = 0.01）。这些患者中高密度脂蛋白胆固醇、载脂蛋白AI水平较低（p = 0.001）。与对照组相比，aCL阳性和阴性的RA患者中脂蛋白（a）水平均较高（分别为P = 0.001和p = 0.01）。
aCL的存在和血脂谱改变可能是RA患者血栓形成事件的重要危险因素。
