Tong S, Frasier I D, Ingenito S, Sica A L, Gootman N, Gootman P M
Department of Physiology, SUNY-Health Science Center at Brooklyn 11203, USA.
Pediatr Res. 1997 Jan;41(1):72-7. doi: 10.1203/00006450-199701000-00011.
The effects of right stellate ganglionectomy (RSG) and bilateral stellate ganglionectomy (BSG) on cardiovascular responses to phenyl biguanide (PBG, 80 micrograms/kg) were studied in 1- and 8-wk-old piglets. Animals were anesthetized with Saffan, paralyzed, thoractomized, and ventilated with 100% O2. Recordings of the ECG (lead II) and aortic pressure (AoP) were used to compute the maximum R-R interval, heart rate (HR), and mean AoP, and to determine the occurrence of atrioventricular conduction block (AVB). Right atrial injections of PBG in 1-wk-old piglets elicited AVB as well as decreases in AoP and HR in all animals; this response pattern was not altered by either RSG or BSG. The PBG response of neurally intact 8-wk-old animals was comprised of a decrease of HR without change in AoP; AVB occurred in three of six animals. After RSG or BSG, AoP decreased along with decreased HR, and now AVB occurred in all animals; changes of AoP and maximum R-R interval were greater after BSG than after RSG. These results suggest that the stellate ganglia exert a neuroprotective influence on cardiovascular function, requiring some degree of maturation for expression. Our findings support the hypothesis that an imbalance of cardiac autonomic innervation favoring parasympathetic activity may produce immature responses to cardiopulmonary afferent stimulation in older maturing animals.
在1周龄和8周龄的仔猪中，研究了右侧星状神经节切除术（RSG）和双侧星状神经节切除术（BSG）对苯双胍（PBG，80微克/千克）心血管反应的影响。动物用三碘季铵酚麻醉，使其麻痹，进行开胸手术，并使用100%氧气进行通气。记录心电图（II导联）和主动脉压力（AoP），用于计算最大R-R间期、心率（HR）和平均AoP，并确定房室传导阻滞（AVB）的发生情况。在1周龄仔猪的右心房注射PBG，在所有动物中均引起AVB以及AoP和HR降低；这种反应模式未被RSG或BSG改变。神经完整的8周龄动物对PBG的反应包括HR降低而AoP无变化；六只动物中有三只发生AVB。在RSG或BSG后，AoP随着HR降低而降低，并且现在所有动物均发生AVB；BSG后AoP和最大R-R间期的变化比RSG后更大。这些结果表明，星状神经节对心血管功能发挥神经保护作用，其表达需要一定程度的成熟。我们的研究结果支持这样的假设，即在成熟后期的动物中，有利于副交感神经活动的心脏自主神经支配失衡可能会导致对心肺传入刺激产生不成熟的反应。
