Gootman P M, Buckley B J, DiRusso S M, Gootman N, Yao A C, Pierce P E, Griswold P G, Epstein M D, Cohen H L, Nudel D B
Am J Physiol. 1986 Oct;251(4 Pt 2):H748-55. doi: 10.1152/ajpheart.1986.251.4.H748.
Cardiovascular responses to stimulation of cardiopulmonary receptors were evaluated in standard breed developing swine (1-2 days, 1-2 wk, and 2 mo of age) and sexually mature miniswine anesthetized with 0.25-0.50% halothane in O2. Cryptenamine, a mixture of veratrum viride alkaloids (VVA), was administered as right atrial or left ventricular bolus injections in doses of 5-20 micrograms/kg. In developing swine, mean aortic pressure (AoP) decreased after 10-20 micrograms/kg VVA in 1- to 2-wk olds and after 5-20 micrograms/kg VVA in 2-mo olds. Bradycardia was always elicited. Renal (Ren) and femoral (Fem) vasodilation occurred in the 1- to 2-wk-old and 2-mo-old groups after 5-20 micrograms/kg VVA. Mesenteric (Mes) vasodilation was elicited with 10-20 micrograms/kg VVA in the 1- to 2-wk-old group and with 5-20 micrograms/kg VVA in 2-mo olds. In the 1- to 2-day-old group, VVA did not significantly alter Ren, Fem, and Mes vascular resistance. In mature miniswine, 20 micrograms/kg VVA elicited decreases in AoP and heart rate that were similar in magnitude to responses obtained with only 5 micrograms/kg VVA in dogs. Cardiovascular responses to VVA were abolished after bilateral vagotomy but were not altered after denervation of the carotid sinuses. The results indicate postnatal maturation of the Bezold-Jarisch reflex in swine.
在标准品种的生长猪（1 - 2日龄、1 - 2周龄和2月龄）以及用0.25 - 0.50%氟烷在氧气中麻醉的性成熟小型猪中，评估了对心肺感受器刺激的心血管反应。藜芦胺，一种藜芦生物碱（VVA）的混合物，以5 - 20微克/千克的剂量作为右心房或左心室推注给药。在生长猪中，1 - 2周龄的猪在给予10 - 20微克/千克VVA后平均主动脉压（AoP）下降，2月龄的猪在给予5 - 20微克/千克VVA后平均主动脉压下降。总是会引发心动过缓。在给予5 - 20微克/千克VVA后，1 - 2周龄和2月龄组出现肾（Ren）和股（Fem）血管舒张。在1 - 2周龄组，给予10 - 20微克/千克VVA可引发肠系膜（Mes）血管舒张，在2月龄组，给予5 - 20微克/千克VVA可引发肠系膜血管舒张。在1 - 2日龄组，VVA未显著改变肾、股和肠系膜血管阻力。在成熟小型猪中，20微克/千克VVA引起的AoP和心率下降幅度与犬仅给予5微克/千克VVA时获得的反应相似。双侧迷走神经切断术后，对VVA的心血管反应消失，但颈动脉窦去神经支配后反应未改变。结果表明猪贝佐尔德 - 雅里什反射的出生后成熟。
