Bagga A, Vasudev A S, Moudgil A, Srivastava R N
Department of Paediatrics, All India Institute of Medical Sciences, New Delhi.
Indian J Med Res. 1996 Nov;104:292-5.
Lymphocyte subsets in the peripheral blood were examined in 34 patients with nephrotic syndrome [27 with minimal change nephrotic syndrome (MCNS), 7 with significant lesions] and 10 normal children. The investigations were done at the onset of disease before administering corticosteroids (n = 34), during the subsequent remission (n = 27), and the first relapse (n = 12). The proportions of T cell subsets (CD3, CD4 and CD8) were determined by immuno-alkaline phosphatase staining; interleukin-2 receptor (IL-2 R) positive cells, natural killer (NK) cells and B cells were studied by indirect immunofluorescence. No significant differences were found in the proportion of CD3, CD4, CD8 and IL-2 R positive cells in patients with MCNS as compared to controls. An increased proportion of NK and B cells was not specific to MCNS and was detected even in those with significant renal lesions. Our findings suggest that T lymphocyte subsets in MCNS are similar to those in normal children.
对34例肾病综合征患者[27例微小病变型肾病综合征（MCNS），7例有明显病变者]及10名正常儿童的外周血淋巴细胞亚群进行了检测。检测在疾病发作时（未使用糖皮质激素，n = 34）、随后的缓解期（n = 27）以及首次复发时（n = 12）进行。通过免疫碱性磷酸酶染色确定T细胞亚群（CD3、CD4和CD8）的比例；通过间接免疫荧光研究白细胞介素-2受体（IL-2 R）阳性细胞、自然杀伤（NK）细胞和B细胞。与对照组相比，MCNS患者中CD3、CD4、CD8和IL-2 R阳性细胞的比例未发现显著差异。NK细胞和B细胞比例增加并非MCNS所特有，在有明显肾脏病变的患者中也能检测到。我们的研究结果表明，MCNS中的T淋巴细胞亚群与正常儿童相似。
