Nagesha C N, Shenoy K J, Chandrashekar M R
Department of Microbiology, Dr BR Ambedkar Medical College, Bangalore.
J Indian Med Assoc. 1996 Jun;94(6):230-3.
Fifty cases of burn of different degrees were subjected to clinical and microbiological studies. A total of 60 isolates were obtained. Of these, 40 (80.0% incidences) were Ps aeruginosa, 8 (16.0 incidences) Staph pyogenes, 6 (12.0% incidences) Kl pneumoniae, 4 (80.0% incidences) Esch coli and 2 (4.0% incidences) C albicans. Monobacterial cultures showed isolations in 41 cases (82.0%) and 34 (68.0%) of them were Ps aeruginosa. At the time to admission 42 cases (84.0%) were infected and during one week of hospitalisation another 8 cases (16.0%) were infected yielding an overall infection rate of 100%. The commonest organism on admission and after hospitalisation was Ps aeruginosa with isolation rates of 60.0% (30) and 20.0% (10) respectively. Gram-negative bacilli, predominantly Ps aeruginosa were found in the lower part of the body with an incidence of 74.0% (37). Staph pyogenes was found in the upper half showing an incidence of 12.0% (6) next to 20.0% (10) incidence of Ps aeruginosa. The incidence of burn infection was high in patients with deep and major burn wounds, the bacterial isolates being 76.0% (38) and 80.0% (40) respectively. Silver sulphadiazine exhibited antimicrobial action in the range of 14 to 390 microM/ml, while cerium sulphadiazine had no inhibitory effect even up to 667 microM/ml on pseudomonas isolates. Zinc sulphadiazine was effective in inhibiting the growth of 10 isolates tested in 40 to 297 microM/ml range.
对50例不同程度烧伤患者进行了临床和微生物学研究。共获得60株分离菌。其中，铜绿假单胞菌40株（发生率80.0%），化脓性链球菌8株（发生率16.0%），肺炎克雷伯菌6株（发生率12.0%），大肠杆菌4株（发生率8.0%），白色念珠菌2株（发生率4.0%）。单一细菌培养在41例（82.0%）中显示有分离菌，其中34例（68.0%）为铜绿假单胞菌。入院时42例（84.0%）被感染，住院一周内又有8例（16.0%）被感染，总感染率为100%。入院时和住院后的最常见病原体均为铜绿假单胞菌，分离率分别为60.0%（30株）和20.0%（10株）。革兰氏阴性杆菌，主要是铜绿假单胞菌，在身体下部的发生率为74.0%（37株）。化脓性链球菌在上半身被发现，发生率为12.0%（6株），仅次于铜绿假单胞菌20.0%（10株）的发生率。深度和大面积烧伤创面患者烧伤感染发生率较高，细菌分离率分别为76.0%（38株）和80.0%（40株）。磺胺嘧啶银在14至390微摩尔/毫升范围内表现出抗菌作用，而磺胺嘧啶铈即使高达667微摩尔/毫升对假单胞菌分离株也没有抑制作用。磺胺嘧啶锌在40至297微摩尔/毫升范围内对所测试的10株分离菌有效抑制生长。
