Bahadir I, James E C, Fedde C W
Surg Gynecol Obstet. 1977 Oct;145(4):497-500.
Skin and soft tissue necrosis, in association with the coumarin derivatives, characteristically afflicts females between the third and tenth days of treatment. Anatomic regions abundant in subcutaneous fat are most commonly affected. Many of these patients have underlying serious medical problems. Three additional patients with tissue infarction complicating coumadin therapy are presented. Possible etiologic mechanisms are discussed, but the basic physiopathologic condition remains an enigma. Venous thrombosis can be a related clinical phenomenon. Treatment perspectives are outlined.
皮肤和软组织坏死与香豆素衍生物有关，其典型特征是在治疗的第三天至第十天折磨女性患者。皮下脂肪丰富的解剖区域最常受累。这些患者中有许多存在潜在的严重医疗问题。本文还介绍了另外三名在华法林治疗过程中出现组织梗死并发症的患者。文中讨论了可能的病因机制，但基本的病理生理状况仍然是个谜。静脉血栓形成可能是一种相关的临床现象。本文概述了治疗前景。
