Chim C S, Chan A C, Kwong Y L, Liang R
Department of Medicine, Queen Mary Hospital, Hong Kong.
Am J Hematol. 1997 Jan;54(1):79-83. doi: 10.1002/(sici)1096-8652(199701)54:1<79::aid-ajh13>3.0.co;2-5.
Primary cardiac lymphoma is a rare entity. We report on the clinicopathological features of 2 patients with primary cardiac lymphomas: one involving the right atrium resulting in intractable right heart failure, and the other involving the pericardium with massive pericardial effusion. In the first patient, sternotomy and surgical biopsy of the tumor were performed to arrive at the diagnosis. In the second patient, CT thorax and transesophageal echocardiography helped to diagnose the pericardial tumor, and cytological examination of the pericardial fluid established the pathological diagnosis of lymphoma. Combination chemotherapy (COPP) was started in both patients. The first patient died on the first day of chemotherapy due to intractable heart failure, while the second attained a partial response to chemotherapy but died of progressive disease 8 weeks later. This is followed by a literature review of 21 patients with primary cardiac lymphoma. In conclusion, the prognosis of primary cardiac tumor remains poor.
原发性心脏淋巴瘤是一种罕见的疾病。我们报告了2例原发性心脏淋巴瘤患者的临床病理特征：1例累及右心房，导致难治性右心衰竭；另1例累及心包，伴有大量心包积液。在第1例患者中，通过胸骨切开术和肿瘤手术活检得出诊断。在第2例患者中，胸部CT和经食管超声心动图有助于诊断心包肿瘤，心包积液的细胞学检查确立了淋巴瘤的病理诊断。2例患者均开始联合化疗（COPP）。第1例患者在化疗第1天因难治性心力衰竭死亡，而第2例患者化疗后获得部分缓解，但8周后死于疾病进展。随后对21例原发性心脏淋巴瘤患者进行了文献综述。总之，原发性心脏肿瘤的预后仍然很差。
