巴佛洛霉素A1与嗜肺军团菌的细胞内增殖
Bafilomycin A1 and intracellular multiplication of Legionella pneumophila.
作者信息
Cattani L, Goldoni P, Pastoris M C, Sinibaldi L, Orsi N
机构信息
Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Università La Sapienza, Rome, Italy.
出版信息
Antimicrob Agents Chemother. 1997 Jan;41(1):212-4. doi: 10.1128/AAC.41.1.212.
Abstract
Multiplication of Legionella pneumophila in HeLa cells was found to be inhibited by noncytotoxic concentrations of bafilomycin A1, with blockage of bacterial growth at a concentration 15.6 nM. The inhibiting action was evident only when the antibiotic was present during the initial phase of intracellular multiplication, i.e., during the formation of the phagosome, whereas the addition of the drug did not affect microorganisms already actively multiplying within the phagosome.
摘要
发现非细胞毒性浓度的巴弗洛霉素A1可抑制嗜肺军团菌在HeLa细胞中的增殖，在浓度为15.6 nM时可阻断细菌生长。仅当抗生素在细胞内增殖的初始阶段即吞噬体形成期间存在时，抑制作用才明显，而添加该药物并不影响已经在吞噬体内活跃增殖的微生物。
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