威布尔函数对利巴韦林在人体中的药代动力学数据进行拟合。
Weibull function fits to pharmacokinetic data of ribavirin in man.
作者信息
Liu X D, Xie L, Han K Q, Liu G Q
机构信息
Department of Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu Province, People's Republic of China.
出版信息
Eur J Drug Metab Pharmacokinet. 1996 Jul-Sep;21(3):227-31. doi: 10.1007/BF03189718.
Weibull function C = Bts-1exp(-lambda ts) was used to describe plasma concentration-time data of ribavirin in 6 healthy subjects following an i.v. dose of 600 mg. A good fit was found in each of the subjects, where the coefficients of determination r2 were > 0.99. The parameters estimated were as follows: B, 5.90 +/- 1.86 micrograms.h1-s; lambda, 0.607 +/- 0.156 h-s; and s, 0.339 +/- 0.085, respectively. The results were compared with those by triexponential function. By providing lower values of AIC and SD, as well as higher values of r2, the Weibull function proved to be superior to triexponential function for data of 3 subjects. These results indicated that both Weibull function and triexponential function provided a good fit of plasma concentration-time data of ribavirin in man following an i.v. dose.
威布尔函数(C = Bt^{s - 1}\exp(-\lambda t^{s}))用于描述6名健康受试者静脉注射600mg利巴韦林后的血浆浓度-时间数据。在每个受试者中均发现拟合良好，其中决定系数(r^{2}\gt0.99)。估计的参数如下：(B)为(5.90\pm1.86)微克·(h^{1 - s})；(\lambda)为(0.607\pm0.156) (h^{- s})；(s)为(0.339\pm0.085)。将结果与用三指数函数得到的结果进行比较。通过提供更低的AIC和SD值以及更高的(r^{2})值，对于3名受试者的数据，威布尔函数被证明优于三指数函数。这些结果表明，威布尔函数和三指数函数均能很好地拟合人静脉注射利巴韦林后的血浆浓度-时间数据。
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